Joseph Randle (at NO)
It seems like it would be an injustice to disregard Joseph Randle this week against the New Orleans Saints. The Saints are struggling on the defensive side of the ball right now, and the Cowboys are going to take their traveling "Joseph Randle Touchdown Show" into New Orleans.
Last week, Randle rushed for three touchdowns, and he touched the ball at an alarming rate. Brandon Weeden's goal is clearly to hand the ball off and win enough games to keep the Cowboy's season alive until Tony Romo returns. Randle was a threat even with Tony Romo at the helm, but he is even more of a threat now that he is almost guaranteed to touch the ball 25-30 times a game.
Karlos Williams (vs NYG)
Williams' price took a bit of a jump on daily league sites, but it is still entirely too cheap. LeSean McCoy is going to miss this game, which means Williams will get the lion's share of the touches. He's averaging 7.8 yards per carry on the season, recording 186 yards and 3 touchdowns on 24 carries.
Since McCoy is out, Williams could double his attempts on the season, which gives him great upside. He also gets a matchup against a weak Giants run defense, and Williams should be used in all leagues this week.