T.J. Yeldon is getting an incredible market share of Jacksonville's backfield work, and has a good chance at returning 4x value. Not to mention if Andrew Luck doesn't go for the Colts, I think Yeldon could provide amazing return in a game where the Jaguars won't have to abandon the run.
I think I would look elsewhere if Luck plays, but Yeldon still might do well. The Colts have a decent run defense, but if Luck is out this game profiles a lot more like the Jags Week 2 tilt against the Dolphins rather than the Week 3 game against the Patriots. In Week 2 Yeldon was on the field for 85% of snaps, showing me that Jags OC Greg Olson wasn't blowing smoke when he said he wanted to run the ball a lot.
Toby Gerhart is back, but he doesn't pose much of a threat and T.J. Yeldon should be a sneaky play in Week 4 if Luck sits and the Jags can control the game.