The Giants don't have the names and notoriety that the Jets have, but their defense has been profiling pretty similarly.
They have a very strong run defense unit, and their cornerbacks on the outside are typically strong - though now they are without Prince Amukamura, and their slot corner Trumaine McBride missed practice as well.
The Giants are very susceptible over the middle with inexperienced and overmatched safeties and linebackers. Last week against the Saints, Ertz got five receptions for 60 yards on seven targets, and if he can replicate that and tack on a touchdown then you've made great value in your Week 6 lineups.