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In this article, I will be providing you with my weekly fantasy football lineup picks on OwnersBox for contests that start in Week 6. I will pick out two players at each position: a short-term option (for one-week drafts) and a long-term option (for drafts lasting between two and four weeks). As always, be sure to monitor news from the league in this crazy COVID-19 season. Game postponements and cancellations can happen at any time.
Be sure to also check out our other great NFL DFS articles and NFL DFS tools to help you win big no matter what your preferred weekly fantasy platform happens to be. If you sign up for OwnersBox this week, you'll get $25 free in OwnersBucks, which can be redeemed to play in real money games.
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OwnersBox Quarterbacks
Patrick Mahomes (Kansas City Chiefs) @BUF
Mahomes and the Chiefs travel to Buffalo in what should be one of the highest-scoring games on the slate. The Bills have struggled against the pass in the early going, ranking just 24th in pass defense DVOA and allowing the fourth-most fantasy points per game to the position. Mahomes as the top QB off the board in one-week drafts in a no-brainer.
Also consider: Josh Allen (Buffalo Bills) vs. KC
Cam Newton (New England Patriots) vs. DEN, vs. SF, @BUF, @NYJ
Newton has tested negative for COVID-19 after missing a handful of weeks and will presumably be back under center in Week 6 against the Broncos. Denver's pass defense ranks 18th in DVOA and is allowing the seventh-most fantasy points per game to quarterbacks. In Week 7, he will take on the 49ers at home. San Francisco's once-dominant defense has crumbled in 2020. After allowing Ryan Fitzpatrick to shred them in Week 5, the 49ers are allowing the 14th-most fantasy points per game and rank 23rd in DVOA vs. the pass.
Week 8 brings a fantastic road matchup against the Bills. Revisit the Patrick Mahomes section above to see just how generous Buffalo has been to opposing passing offenses this season. Newton finishes up this fantastic four-game stretch with a road matchup against the Jets. New York's pass-funnel defense ranks 31st in pass DVOA and ninth against the run.
Also consider: Ben Roethlisberger (Pittsburgh Steelers) vs. CLE, @TEN, @BAL, @DAL
OwnersBox Running Backs
Derrick Henry (Tennessee Titans) vs. HOU
Henry found the end zone twice more in Week 5's Tuesday night game and delivered a vicious stiff-arm to cornerback Josh Norman, which you can check out below. The veteran running back is a good bet to score again in Week 6 against a Houston run defense that is allowing the seventh-most fantasy points per game to running backs.
Derrick Henry epic stiff-arm!
Also consider: Mike Davis (Carolina Panthers) vs. CHI
Ezekiel Elliott (Dallas Cowboys) vs. ARI, @WAS, @PHI, vs. PIT
Elliott is always an excellent fantasy option and he could see his team's offense skew a bit more run-heavy after the season-ending injury to Dak Prescott. He will face the Cardinals in Week 6 in what should be a high-scoring game. Look for Dallas to be in the red zone plenty against the Cardinals Defense. In Week 7, Elliott will square off against Washington on the road. Washington is tough against the pass but just average vs. the run, which bodes well for Zeke's outlook.
A road matchup against the Eagles follows. Philly ranks 15th in run defense DVOA. The only tough matchup in this four-game stretch is Elliott's Week 9 showdown with the Steelers. Pittsburgh's run defense has been tough but they did show some cracks, allowing Miles Sanders to score twice in Week 5.
Also consider: Aaron Jones (Green Bay Packers) @TB, @HOU, vs. MIN, @SF
OwnersBox Wide Receivers
DeAndre Hopkins (Arizona Cardinals) @DAL
Hopkins proved he has over a Week 4 ankle injury last week, popping off for 131 yards and a score against the Jets last week. He draws a pristine matchup against a leaky Dallas secondary in Week 6. The Cowboys are allowing the third-most WR fantasy points per game this season, giving up big games to Robert Woods, Calvin Ridley, Tyler Lockett, D.K. Metcalf, Odell Beckham Jr., and Darius Slayton. Hopkins is a smash selection as the first WR off the board.
Also consider: Kenny Golladay (Detroit Lions) @JAX
Davante Adams (Green Bay Packers) @TB, @HOU, vs. MIN, @SF
Adams struggled with a hamstring injury over the first few weeks of the season but he was reportedly close to playing in Week 4. He should be close to 100% coming off a Week 5 bye. When Adams is healthy, he is one of the safest, highest-ceiling WRs in fantasy, thanks to the lack of receiving options around him. He will take on Tampa Bay in Week 6 in what is a tough matchup. Of course, I like his chances any week regardless of matchup difficulty. Week 7 brings a road matchup against a Houston pass defense that has been very average against the pass this season.
The Vikings have been one of the top matchups for receivers this season, having allowed the sixth-most fantasy points per game to the position through the first five weeks. Adams finishes up with the 49ers in Week 9. San Francisco's pass defense ranks just 23rd in pass defense DVOA. They are also much tougher against the run, which should push even more work onto Adams' plate.
Also consider: Tyreek Hill (Kansas City Chiefs) @BUF, @DEN, vs. NYJ, vs. CAR
OwnersBox Tight Ends
Mark Andrews (Baltimore Ravens) @PHI
Andrews has been up-and-down this season but he's on a hot streak of late, having caught three touchdowns in his last two games. He will take on an Eagles Defense that is allowing the fourth-most fantasy points per game to the tight end position. As the clear No. 1 option in the Baltimore passing game, Andrews is likely to find the end zone again this weekend.
Also consider: George Kittle (San Francisco 49ers) vs. LAR
Travis Kelce (Kansas City Chiefs) @BUF, @DEN, vs. NYJ, vs. CAR
Kelce is in a great spot over the next four games of the season. He will face a Bills Defense that is allowing the third-most fantasy points per game to the tight end this weekend. In Week 7, he travels to Denver in another plus matchup. The Broncos have allowed the 11th-most FPP to the position.
The Jets pass defense is one of the worst in the league, as mentioned above in the Cam Newton section, and has allowed three touchdowns to tight ends over the past four games. Kelce wraps up this stretch against the Panthers in his only "tough" matchup on the slate. Carolina has been stingy against enemy tight ends but they haven't faced anyone on the level of Kelce this season.
Also consider: Jonnu Smith (Tennessee Titans) vs. HOU, vs. PIT, @CIN, vs. CHI
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